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Concurrent weekly nedaplatin, external beam radiotherapy and high-dose-rate brachytherapy in patients with FIGO stage IIIb cervical cancer: a comparison with a cohort treated by radiotherapy alone.
- Source :
-
Gynecologic and obstetric investigation [Gynecol Obstet Invest] 2010; Vol. 69 (4), pp. 224-232. Date of Electronic Publication: 2010 Jan 07. - Publication Year :
- 2010
-
Abstract
- Objectives: The aim of this study was to evaluate whether nedaplatin-based concurrent chemoradiotherapy (CCRT) using high-dose-rate intracavitary brachytherapy (HDR-ICBT) is superior to radiotherapy (RT) alone in patients with FIGO stage IIIb cervical cancer.<br />Methods: The records of 41 consecutive women treated either with nedaplatin-based CCRT using HDR-ICBT (n = 20) or RT alone (nonrandomized control group, n = 21) for stage IIIb cervical cancer were retrospectively reviewed. The activity and toxicity were compared between the two treatment groups. Progression-free survival (PFS) and overall survival (OS) were the main endpoints.<br />Results: The 5-year overall survival rates in the CCRT and RT groups were 65 and 33.3%, respectively. The median OS of the CCRT and RT groups were 60 and 29 months, respectively. CCRT was significantly superior to RT alone with regard to PFS (p = 0.0015) and OS (p = 0.0364). The frequency of acute grade 3-4 toxicity was significantly higher in the CCRT group than in the RT group. However, no statistically significant difference was observed with regard to severe late toxicity.<br />Conclusions: Nedaplatin-based concurrent chemoradiotherapy was safely performed and significantly improved the prognosis of patients with FIGO stage IIIb cervical cancer. This treatment can be considered as an alternative to cisplatin-based chemoradiotherapy in this patient population.<br /> (Copyright (c) 2010 S. Karger AG, Basel.)
- Subjects :
- Aged
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell radiotherapy
Combined Modality Therapy adverse effects
Disease-Free Survival
Female
Humans
Middle Aged
Neoplasm Staging
Organoplatinum Compounds adverse effects
Retrospective Studies
Treatment Outcome
Uterine Cervical Neoplasms pathology
Antineoplastic Agents administration & dosage
Brachytherapy adverse effects
Organoplatinum Compounds administration & dosage
Uterine Cervical Neoplasms drug therapy
Uterine Cervical Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 1423-002X
- Volume :
- 69
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Gynecologic and obstetric investigation
- Publication Type :
- Academic Journal
- Accession number :
- 20068328
- Full Text :
- https://doi.org/10.1159/000273207