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Short-duration furazolidone therapy in combination with amoxicillin, bismuth subcitrate, and omeprazole for eradication of Helicobacter pylori.
- Source :
-
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association [Saudi J Gastroenterol] 2010 Jan-Mar; Vol. 16 (1), pp. 14-8. - Publication Year :
- 2010
-
Abstract
- Background/aim: Resistance to metronidazole is one of the most common reasons for Helicobacter pylori treatment failure with the classic triple therapy. The clarithromycin-based regimen is not cost-effective for use in developing countries. Though furazolidone is a great substitute it has many side effects. Decreasing the duration of treatment with furazolidone to 1 week may help decrease the drug's side effects.<br />Aim: To study the efficacy and side effects of furazolidone when given for 1 week in combination with bismuth subcitrate, amoxicillin, and omeprazole.<br />Materials and Methods: One hundred and seventy-seven patients with duodenal ulcer were randomly divided into two groups. Group I received omeprazole 2 Chi 20 mg + amoxicillin 2 Chi 1 g + bismuth subcitrate 4 Chi 120 mg for 2 weeks, with furazolidone 2 Chi 200 mg in the first week only. Group II received the same regimen, except that 1 week of furazolidone was followed by 1 week of metronidazole in the second week. Control endoscopy was performed after 6 weeks. Three biopsies from the antrum and three from the corpus were taken for urease testing and histology. Eradication was concluded if all tests were negative for H pylori.<br />Results: One hundred and fifty-seven patients completed the study. Two subjects from group I and three from group II did not tolerate the regimen and were excluded from the analysis. No serious complication was detected in any patient. The eradication rates by per-protocol (PP) analysis and intention-to-treat (ITT) analysis were 89% and 79.3% in group I and 86.6% and 74.4% in group II, respectively.<br />Conclusion: One week of furazolidone in combination with 2 weeks of amoxicillin, omeprazole, and bismuth subcitrate is a safe and cost-effective regimen for the eradication of H pylori. Adding metronidazole to the above regimen does not increase the eradication rate.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Amoxicillin administration & dosage
Drug Therapy, Combination
Duodenal Ulcer microbiology
Female
Furazolidone administration & dosage
Humans
Male
Middle Aged
Omeprazole administration & dosage
Organometallic Compounds administration & dosage
Time Factors
Treatment Outcome
Anti-Bacterial Agents administration & dosage
Anti-Ulcer Agents administration & dosage
Duodenal Ulcer drug therapy
Helicobacter Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1998-4049
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
- Publication Type :
- Academic Journal
- Accession number :
- 20065568
- Full Text :
- https://doi.org/10.4103/1319-3767.58762