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Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia.
- Source :
-
Neurology [Neurology] 2010 Jan 12; Vol. 74 (2), pp. 121-7. - Publication Year :
- 2010
-
Abstract
- Objective: To investigate whether global and regional beta-amyloid (Abeta) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD).<br />Methods: Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using 11C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group.<br />Results: In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group.<br />Conclusions: The strong correlation between hippocampal atrophy and beta-amyloid (Abeta) burden in the Pittsburgh compound B-positive healthy control group suggests that Abeta deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.
- Subjects :
- Age Factors
Aged
Aged, 80 and over
Aging metabolism
Aging pathology
Algorithms
Aniline Compounds
Atrophy diagnostic imaging
Atrophy metabolism
Biomarkers analysis
Biomarkers metabolism
Brain Mapping methods
Carbon Radioisotopes
Cohort Studies
Disease Progression
Female
Hippocampus diagnostic imaging
Hippocampus metabolism
Humans
Image Processing, Computer-Assisted methods
Magnetic Resonance Imaging methods
Male
Middle Aged
Neocortex diagnostic imaging
Neocortex metabolism
Nerve Degeneration diagnostic imaging
Nerve Degeneration metabolism
Nerve Degeneration pathology
Plaque, Amyloid metabolism
Positron-Emission Tomography methods
Severity of Illness Index
Temporal Lobe diagnostic imaging
Temporal Lobe metabolism
Thiazoles
Amyloid beta-Peptides metabolism
Atrophy pathology
Hippocampus pathology
Neocortex pathology
Plaque, Amyloid pathology
Temporal Lobe pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 20065247
- Full Text :
- https://doi.org/10.1212/WNL.0b013e3181c918b5