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Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure.
- Source :
-
International journal of cardiology [Int J Cardiol] 2010 Nov 19; Vol. 145 (2), pp. 333-334. Date of Electronic Publication: 2010 Jan 08. - Publication Year :
- 2010
-
Abstract
- It has been reported that angiotensin converting enzyme (ACE) 2, a homologue of ACE, has direct effects on cardiac function. However, the role of ACE2 in the development of human heart failure is not fully understood. We evaluated the expression of the ACE2 gene by means of real-time RT-PCR in myocardium from 14 patients with end-stage heart failure. The amount of ACE2 mRNA positively correlated with left ventricular (LV) end-diastolic diameter (r(2)=0.56, p<0.01) but did not significantly correlate with LV ejection fraction or plasma brain natriuretic peptide levels. In conclusion, our data show that the up-regulation of the ACE2 gene in the LV myocardium of patients with severe heart failure was associated with the degree of LV dilatation and may thereby constitute an important adaptive mechanism to retard the progression of adverse LV remodeling.<br /> (Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Angiotensin-Converting Enzyme 2
Biomarkers metabolism
Female
Heart Failure diagnosis
Humans
Male
Middle Aged
Myocardium enzymology
Myocardium pathology
Gene Expression Regulation, Enzymologic
Heart Failure enzymology
Peptidyl-Dipeptidase A biosynthesis
Ventricular Remodeling physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 145
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Report
- Accession number :
- 20060185
- Full Text :
- https://doi.org/10.1016/j.ijcard.2009.11.057