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Photonic approach to the selective inactivation of viruses with a near-infrared subpicosecond fiber laser.
- Source :
-
Journal of biomedical optics [J Biomed Opt] 2009 Nov-Dec; Vol. 14 (6), pp. 064042. - Publication Year :
- 2009
-
Abstract
- We report a photonic approach for selective inactivation of viruses with a near-infrared subpicosecond laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as the M13 bacteriophage and the tobacco mosaic virus to pathogenic viruses such as the human papillomavirus and the human immunodeficiency virus (HIV). At the same time, sensitive materials such as human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. The laser technology targets the global mechanical properties of the viral protein shell, making it relatively insensitive to the local genetic mutation in the target viruses. As a result, the approach can inactivate both the wild and mutated strains of viruses. This intriguing advantage is particularly important in the treatment of diseases involving rapidly mutating viral species such as HIV. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.
- Subjects :
- Alphapapillomavirus physiology
Alphapapillomavirus radiation effects
Animals
Bacteriophage M13 physiology
Bacteriophage M13 radiation effects
Cells, Cultured
Dendritic Cells radiation effects
Erythrocytes radiation effects
HIV physiology
HIV radiation effects
Humans
Jurkat Cells radiation effects
Mice
Microscopy, Atomic Force
Tobacco Mosaic Virus physiology
Tobacco Mosaic Virus radiation effects
Lasers
Optics and Photonics methods
Spectroscopy, Near-Infrared methods
Virus Inactivation radiation effects
Viruses radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1560-2281
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of biomedical optics
- Publication Type :
- Academic Journal
- Accession number :
- 20059280
- Full Text :
- https://doi.org/10.1117/1.3275477