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Response to methylphenidate is not influenced by DAT1 polymorphisms in a sample of Brazilian adult patients with ADHD.
- Source :
-
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2010 Feb; Vol. 117 (2), pp. 269-76. Date of Electronic Publication: 2010 Jan 05. - Publication Year :
- 2010
-
Abstract
- Several lines of evidence suggest a relevant role for the dopamine transporter (DAT1) gene not only as a susceptibility factor for attention-deficit hyperactivity disorder (ADHD), but also as a predictor of individual methylphenidate (MPH) response. Pharmacogenetic studies of MPH response in ADHD have mainly focused on the 40-bp variable number of tandem repeats (VNTR) in the 3' untranslated region (3'-UTR) of DAT1. Most studies were performed in samples of children and conflicting findings were obtained. Only two studies have assessed 3'-VNTR in samples of adults-one with positive and the other with negative findings. In the present study, we investigate three potentially relevant polymorphisms in DAT1 gene (-839 C > T; Int8 VNTR and 3'-VNTR), and their possible role in therapeutic response to MPH treatment in a sample of 171 Brazilian adults with ADHD. The diagnostic procedures followed the DSM-IV criteria and the outcome measures were the scales Swanson, Nolan, and Pelham Rating scale version IV and the Clinical Global Impression-Severity Scale, applied at the beginning and after the 30th day of treatment. Drug response was assessed by both categorical and dimensional approaches. There was no effect of any DAT1 polymorphisms or haplotypes on MPH response. This is the second report demonstrating absence of differences in MPH response according to DAT1 genotypes in adults with ADHD. Although DAT protein is crucial for the effect of MPH, genetic variations in DAT1 gene probably do not have a significant clinical role in this sample of adults with ADHD.
- Subjects :
- 3' Untranslated Regions
Adult
Brazil
Female
Genotype
Haplotypes
Humans
Male
Psychiatric Status Rating Scales
Treatment Outcome
Attention Deficit Disorder with Hyperactivity drug therapy
Attention Deficit Disorder with Hyperactivity genetics
Dopamine Plasma Membrane Transport Proteins genetics
Dopamine Uptake Inhibitors therapeutic use
Methylphenidate therapeutic use
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1435-1463
- Volume :
- 117
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neural transmission (Vienna, Austria : 1996)
- Publication Type :
- Academic Journal
- Accession number :
- 20049490
- Full Text :
- https://doi.org/10.1007/s00702-009-0362-2