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Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7.
- Source :
-
Anticancer research [Anticancer Res] 2009 Dec; Vol. 29 (12), pp. 4933-40. - Publication Year :
- 2009
-
Abstract
- Aim: To define specific staining patterns for the adhesion/growth-regulatory lectin tandem-repeat-type galectin-8 in hypopharyngeal and laryngeal tumor progression and relate these parameters to galectins 1, 3 and 7 in the quest to explore the galectin network.<br />Materials and Methods: The level of expression of galectin-8 was determined immunohistochemically in a series of 18 and 16 cases of tumor-free epithelium, 24 and 10 cases of low-grade dysplasia, 22 and 15 cases of high-grade dysplasia located in peri-tumoral area of 74 and 37 hypopharyngeal and laryngeal carcinomas.<br />Results: Marked upregulation in galectin-8 staining intensity and immunopositive area in malignancy versus dysplasia was seen in hypopharyngeal cancer (p<10(-6)), in laryngeal cancer for labeling index and high-grade dysplasia/carcinoma (p<10(-6)). No correlation to recurrence was delineated.<br />Conclusion: The presented data revealed a divergence within the galectin-1, -3, -7 and -8 network during tumor progression.
- Subjects :
- Adult
Aged
Aged, 80 and over
Animals
Blotting, Western
Carcinoma, Squamous Cell secondary
Carcinoma, Squamous Cell therapy
Combined Modality Therapy
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Galectins immunology
Gene Expression Regulation, Neoplastic
Humans
Hypopharyngeal Neoplasms pathology
Hypopharyngeal Neoplasms therapy
Immunoenzyme Techniques
Laryngeal Neoplasms pathology
Laryngeal Neoplasms therapy
Larynx metabolism
Larynx pathology
Male
Middle Aged
Neoplasm Staging
Pharynx metabolism
Pharynx pathology
Prognosis
Rabbits
Retrospective Studies
Up-Regulation
Carcinoma, Squamous Cell metabolism
Galectin 1 metabolism
Galectin 3 metabolism
Galectins metabolism
Hypopharyngeal Neoplasms metabolism
Laryngeal Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 29
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 20044599