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Expression of mitotic checkpoint proteins BUB1B and MAD2L1 in salivary duct carcinomas.
- Source :
-
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2010 Apr; Vol. 39 (4), pp. 349-55. Date of Electronic Publication: 2009 Dec 16. - Publication Year :
- 2010
-
Abstract
- Objective: Defects in the mitotic checkpoint lead to aneuploidy and might facilitate tumorigenesis. However, the ploidy status in salivary duct carcinoma (SDC) has been reported to play limited role in prediction of prognosis. Thus, we need more reliable markers to reflect the rapid tumor progression in SDCs. We aimed here to investigate the expression of mitotic checkpoint proteins benzimidazole 1 homolog beta (BUB1B) and mitosis arrest-deficient 2 like 1 (MAD2L1) in SDCs and to determine their possible role as surrogate prognostic markers.<br />Methods: We analyzed the clinical courses, pathologic findings and immunohistochemical profiles of mitotic checkpoint proteins (BUB1B and MAD2L1) in 27 pathologically confirmed SDCs. The expression status of BUB1B and MAD2L1 was compared with clinicopathologic factors and other molecular markers, such as TGF-beta, c-erb-B2, androgen receptor, vascular endothelial growth factor, and epidermal growth factor receptor, for prognostic significance.<br />Results: High BUB1B expression was detected in 25.9% of subjects, and high MAD2L1 expression was in 55.6% of subjects. However, survival analysis revealed that mitotic checkpoint expression did not have prognostic significance in SDCs, nor did the other studied markers. Rather, the clinical variable of N classification at diagnosis (in N+ status, hazard ratio 5.19, 95% CI 1.26-21.32 for disease-free survival and hazard ratio 7.18, 95% CI 1.09-46.99 for overall survival) was strongly associated with survival and prognosis based on the Cox proportional hazard model.<br />Conclusions: Mitotic checkpoint proteins appeared to play a limited role in predicting prognosis in SDCs. Further study is required to elucidate the exact role of mitotic checkpoint proteins in SDCs.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor analysis
Carcinoma secondary
Cohort Studies
Disease-Free Survival
ErbB Receptors analysis
Female
Gene Expression Regulation, Neoplastic genetics
Humans
Mad2 Proteins
Male
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Proportional Hazards Models
Receptor, ErbB-2 analysis
Receptors, Androgen analysis
Remission Induction
Survival Rate
Transforming Growth Factor beta analysis
Treatment Outcome
Vascular Endothelial Growth Factor A analysis
Calcium-Binding Proteins analysis
Carcinoma pathology
Cell Cycle Proteins analysis
Protein Serine-Threonine Kinases analysis
Proto-Oncogene Proteins analysis
Repressor Proteins analysis
Salivary Ducts pathology
Salivary Gland Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0714
- Volume :
- 39
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 20040022
- Full Text :
- https://doi.org/10.1111/j.1600-0714.2009.00835.x