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Value of amniotic fluid interleukin-8 for the prediction of histological chorioamnionitis in preterm premature rupture of membranes.
- Source :
-
Neuro endocrinology letters [Neuro Endocrinol Lett] 2009; Vol. 30 (6), pp. 733-8. - Publication Year :
- 2009
-
Abstract
- Objective: To determine whether amniotic fluid levels of interleukin-8 (IL-8) are of value in the antenatal diagnosis of acute histological chorioamnionitis (HCA) in preterm premature rupture of membranes (PPROM).<br />Setting: Department of Obstetrics and Gynaecology, Charles University, Medical School and University Hradec Kralove, Czech Republic.<br />Methods: We compared amniotic fluid IL-8 levels in twenty-nine pregnant women with preterm premature rupture of membranes between 24th and 36th gestational weeks with presence and absence acute histological chorioamnionitis or/and microbial invasion in the amniotic cavity using nonparametric tests (Mann-Whitney test), given the non-normal distribution of analyte. Comparisons of proportions were performed with Shapiro-Wilk normality test.<br />Results: Patients with HCA had a significantly higher median amniotic fluid IL-8 concentration than patients without the histological signs of chorioamnionitis (1867 pg/mL, 826-5577 versus 1045 pg/mL, 60-4133, p=0.013). Patients with MIAC had a significantly higher median amniotic fluid level than patients without invasion (1888 pg/mL, 519-5577 versus 1225 pg/mL, 60-2766, p= 0.017). Women with HCA and MIAC had a significantly higher median amniotic fluid IL-8 level than women without histological signs of chorioamnionitis and microbial invasion (3117 pg/mL, 826-5577 versus 1468 pg/mL, 394-2766, p=0.034).<br />Conclusions: HCA or/and MIAC are associated with a significant increase of amniotic fluid interleukin-8 levels. Amniotic fluid IL-8 seems to be a marker of intraamniotic inflammation.
- Subjects :
- Adult
Amniotic Fluid microbiology
Biomarkers metabolism
Chorioamnionitis microbiology
Female
Fetal Membranes, Premature Rupture microbiology
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Predictive Value of Tests
Pregnancy
Prospective Studies
Ureaplasma isolation & purification
Ureaplasma Infections diagnosis
Ureaplasma Infections metabolism
Amniotic Fluid metabolism
Chorioamnionitis diagnosis
Chorioamnionitis metabolism
Fetal Membranes, Premature Rupture diagnosis
Fetal Membranes, Premature Rupture metabolism
Interleukin-8 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0172-780X
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuro endocrinology letters
- Publication Type :
- Academic Journal
- Accession number :
- 20038922