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Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa.
- Source :
-
Dermatology (Basel, Switzerland) [Dermatology] 2010; Vol. 220 (2), pp. 147-53. Date of Electronic Publication: 2009 Dec 23. - Publication Year :
- 2010
-
Abstract
- Background: To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases.<br />Methods: We propose a clinical and histological analysis of our cases. We include these results in a review of previously reported cases to analyze a total of 65 patients. In our series of 13 cases, we also investigate the presence of human papillomavirus (HPV) in tumor samples, by polymerase chain reaction (PCR) on paraffin-embedded material.<br />Results: Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoanal tumoral lesions, principally HPV-16.<br />Conclusion: SCC complicating HS evolves poorly, despite a good histological prognosis. Our results sustain the implication of HPV in the malignant transformation of HS.
- Subjects :
- Adolescent
Adult
Anus Neoplasms complications
Anus Neoplasms virology
Carcinoma, Squamous Cell complications
Carcinoma, Squamous Cell virology
Carcinoma, Verrucous complications
Carcinoma, Verrucous pathology
Carcinoma, Verrucous virology
Cell Transformation, Neoplastic pathology
Female
Hidradenitis Suppurativa complications
Hidradenitis Suppurativa virology
Humans
Male
Papillomavirus Infections complications
Retrospective Studies
Smoking adverse effects
Urogenital Neoplasms complications
Urogenital Neoplasms virology
Young Adult
Anus Neoplasms pathology
Carcinoma, Squamous Cell pathology
Hidradenitis Suppurativa pathology
Human papillomavirus 16
Papillomavirus Infections pathology
Urogenital Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9832
- Volume :
- 220
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Dermatology (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 20029163
- Full Text :
- https://doi.org/10.1159/000269836