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Effects of acute nitric oxide synthase inhibition on lower leg vascular function in chronic tetraplegia.
- Source :
-
The journal of spinal cord medicine [J Spinal Cord Med] 2009; Vol. 32 (5), pp. 538-44. - Publication Year :
- 2009
-
Abstract
- Background/objective: To improve our understanding of the lower-leg vascular responses of nitric oxide synthase inhibition in persons with tetraplegia.<br />Participants: Six people with chronic tetraplegia and 6 age-matched controls.<br />Methods: Lower-leg relative vascular resistance and venous volume variation were obtained by venous occlusion plethysmography and blood pressure by auscultation at baseline. Postintravenous infusion of the nitric oxide synthase inhibitor NG-nitro-L-arginine-methyl-ester (1 mg x kg(-1) or placebo on separate days.<br />Results: At baseline in the group with tetraplegia compared with controls, mean arterial pressure and relative vascular resistance of the leg were significantly lower. After nitric oxide synthase inhibition, mean arterial pressure and lower leg vascular resistance were significantly elevated in both groups. There were no group or intervention differences in venous volume variation.<br />Conclusion: These preliminary results suggest that nitric oxide synthase inhibition with 1 mg x kg(-1) N(G)-nitro-L-arginine-methyl-ester normalizes seated blood pressure and lower leg vascular resistance to control group baseline levels.
- Subjects :
- Adult
Analysis of Variance
Blood Pressure drug effects
Blood Volume drug effects
Case-Control Studies
Chronic Disease
Enzyme Inhibitors pharmacology
Female
Humans
Male
Middle Aged
NG-Nitroarginine Methyl Ester pharmacology
Plethysmography methods
Enzyme Inhibitors therapeutic use
Leg physiopathology
NG-Nitroarginine Methyl Ester therapeutic use
Nitric Oxide Synthase antagonists & inhibitors
Quadriplegia drug therapy
Quadriplegia pathology
Quadriplegia physiopathology
Vascular Resistance drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1079-0268
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The journal of spinal cord medicine
- Publication Type :
- Academic Journal
- Accession number :
- 20025149
- Full Text :
- https://doi.org/10.1080/10790268.2009.11754555