Subtleties in asymmetric catalyst structure: the resolution of a 6-phospha-2,4,8-trioxa-adamantane and its applications in asymmetric hydrogenation catalysis.

Authors :: Hopewell J
Jankowski P
McMullin CL
Orpen AG
Pringle PG
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2010 Jan 07; Vol. 46 (1), pp. 100-2. Date of Electronic Publication: 2009 Nov 02.
Publication Year :: 2010
Abstract: An efficient, classical resolution of the versatile P-ligand intermediate 6-phospha-2,4,8-trioxa-adamantane (CgPH) is described and the rhodium complex of the optically pure secondary phosphine beta-CgPH is an active and moderately selective asymmetric hydrogenation catalyst.

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