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Late-onset cervicoscapular muscle atrophy and weakness after radiotherapy for Hodgkin disease: a case series.
- Source :
-
Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2010 Jan; Vol. 81 (1), pp. 101-4. - Publication Year :
- 2010
-
Abstract
- Patients with cervical or mediastinal Hodgkin disease (HD) classically underwent chemotherapy plus extended-field radiation therapy. We report six patients who gradually developed severe atrophy and weakness of cervical paraspinal and shoulder girdle muscles 5-30 years after mantle irradiation for HD. Although clinical presentation was uniform, including a dropped head syndrome, electrophysiological and pathological findings were rather heterogeneous. Either neurogenic or myogenic processes may be involved and sometimes combined. We discuss the pathophysiological mechanisms underlying these cervicoscapular motor complications of mantle irradiation in HD.
- Subjects :
- Action Potentials physiology
Adult
Aged
Female
Humans
Male
Middle Aged
Muscle Weakness pathology
Muscle Weakness physiopathology
Muscular Atrophy pathology
Muscular Atrophy physiopathology
Neural Conduction physiology
Time Factors
Hodgkin Disease radiotherapy
Muscle Weakness etiology
Muscular Atrophy etiology
Neck Muscles pathology
Neck Muscles physiopathology
Neck Muscles radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1468-330X
- Volume :
- 81
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 20019226
- Full Text :
- https://doi.org/10.1136/jnnp.2008.167577