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[Establishment of immortalized cell lines and genetic stability evaluation for a family with spinocerebellar ataxia type 2].
- Source :
-
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2009 Aug; Vol. 26 (4), pp. 374-8. - Publication Year :
- 2009
-
Abstract
- Objective: Immortalized cell lines of spinocerebellar ataxia type 2 (SCA2) with Parkinson disease symptoms were established in order to provide experimental material for future study.<br />Methods: The immortalized cell lines were constructed by using Epstein Barr virus and cyclosporine A. Microsatellite markers were detected to see whether there is any change between the cell lines and the original blood samples, and the genetic stability of the cell lines were evaluated.<br />Results: Twenty-five immortalized cell lines were established successfully from the family and the microsatellite markers were unchanged.<br />Conclusion: The karyotypes of the immortal cell lines were normal and the cell lines were genetically stable.
Details
- Language :
- Chinese
- ISSN :
- 1003-9406
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 20017298