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Expression of the difference between the Cold (Han) and Hot (Re) natures of traditional Chinese medicines (Strobal and Rhubarb) based on the cold/hot plate differentiating assay.
- Source :
-
Science in China. Series C, Life sciences [Sci China C Life Sci] 2009 Dec; Vol. 52 (12), pp. 1192-7. Date of Electronic Publication: 2009 Dec 17. - Publication Year :
- 2009
-
Abstract
- In this study, objective differences between the Cold (Han) and Hot (Re) nature of traditional Chinese medicines, e.g. Strobal and Rhubarb, are determined by using a cold/hot plate differentiation technology. A novel, self-designed cold/hot plate differentiating instrument, with methodological study, was used to investigate the intervention of Strobal and Rhubarb on the temperature tropism of mice. Compared with the ICR and BALB/c mice, it was found that KM mice on the cold/hot plate were more sensitive to the change of temperature, within the tolerant temperature range of 15-40 degrees C. The temperature tropism behavior of mice is influenced by treatment with Rhubarb and Strobal, as is the activity of ATPase in liver tissue. These trends are consistent with the definition of the Cold/Hot nature of Chinese medicines based on traditional Chinese medicinal theory. This study showed that the differences of the Cold/Hot nature of traditional Chinese medicines. might be objectively represented by the temperature tropism of animal by means of cold/hot differentiating assay.
- Subjects :
- Animals
Behavior, Animal drug effects
Ca(2+) Mg(2+)-ATPase metabolism
Calcium-Transporting ATPases metabolism
Drugs, Chinese Herbal administration & dosage
Liver drug effects
Liver enzymology
Male
Medicine, Chinese Traditional instrumentation
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Sodium-Potassium-Exchanging ATPase metabolism
Species Specificity
Thermosensing drug effects
Cold Temperature
Drugs, Chinese Herbal pharmacology
Hot Temperature
Medicine, Chinese Traditional methods
Subjects
Details
- Language :
- English
- ISSN :
- 1862-2798
- Volume :
- 52
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Science in China. Series C, Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 20016977
- Full Text :
- https://doi.org/10.1007/s11427-008-0154-1