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Vascular brain disease and depression in the elderly.
- Source :
-
Epidemiology (Cambridge, Mass.) [Epidemiology] 2010 Jan; Vol. 21 (1), pp. 78-81. - Publication Year :
- 2010
-
Abstract
- Background: Cross-sectional studies have shown an association between vascular brain disease and depression. Longitudinal data are scarce. In a population-based study we investigated this relationship both cross-sectionally and longitudinally.<br />Methods: Brain MRIs were administered to 479 persons aged 60-90 years at baseline (1995-1996). Brain atrophy, white matter lesions and brain infarcts are all markers of vascular brain disease. At baseline and at follow-up examinations, we also identified persons with depressive symptoms and syndromes using the Center for Epidemiological Studies Depression Scale and psychiatric interviews. Medical records were continuously monitored to identify incident depression. Follow-up was complete until October 2005.<br />Results: At baseline, 36 persons had depressive symptoms. Brain atrophy, white matter lesions, and infarcts were associated with presence of depressive symptoms. During follow-up, 92 persons developed depressive symptoms, 35 of whom were categorized as having depressive syndrome. There was no association of any MRI marker with incident depressive symptoms or syndromes.<br />Conclusions: Markers of vascular brain disease were associated with depression cross-sectionally. However, when these markers and risk of depression were assessed longitudinally, no relationship was found.
- Subjects :
- Aged
Aged, 80 and over
Cerebrovascular Disorders diagnosis
Cerebrovascular Disorders physiopathology
Cross-Sectional Studies
Depression epidemiology
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Medical Audit
Netherlands epidemiology
Risk Assessment
Cerebrovascular Disorders complications
Depression etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1531-5487
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Epidemiology (Cambridge, Mass.)
- Publication Type :
- Academic Journal
- Accession number :
- 20010211
- Full Text :
- https://doi.org/10.1097/EDE.0b013e3181c1fa0d