Plasma nitrite response in older women to a physical function test.

Authors :: Dobrosielski DA
Presley T
Perlegas A
Marsh AP
Kim-Shapiro D
Rejeski WJ
Source :: Aging clinical and experimental research [Aging Clin Exp Res] 2010 Oct-Dec; Vol. 22 (5-6), pp. 383-6. Date of Electronic Publication: 2009 Dec 14.
Publication Year :: 2010
Abstract: Background and Aims: Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a widely used physical function test on plasma nitrite concentrations in older adults.<br />Methods: Venous blood was drawn before, immediately following, and 10 minutes following the completion of a 400-m walk test. Blood samples were added to heparin and frozen for subsequent analysis of nitrite levels using chemiluminescence.<br />Results: Twenty six (79±4 yrs) women participated in this study. Plasma nitrite levels decreased approximately 22% from baseline following a 400-m walk. Percent change in plasma nitrite was related to walking speed (r=-0.550, p=0.004).<br />Conclusions: These data suggest an alteration in plasma nitrite concentration following a functional test which may impact functional health.