Back to Search
Start Over
Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice.
- Source :
-
Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2010 Feb; Vol. 17 (2), pp. 304-6. Date of Electronic Publication: 2009 Dec 09. - Publication Year :
- 2010
-
Abstract
- We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.
- Subjects :
- Adjuvants, Immunologic administration & dosage
Alum Compounds administration & dosage
Animals
Antibodies, Neutralizing blood
Antibodies, Viral blood
Dengue Vaccines administration & dosage
Injections, Intradermal
Mice
Vaccines, Inactivated administration & dosage
Vaccines, Inactivated immunology
Anti-Infective Agents pharmacology
Dengue Vaccines immunology
Dengue Virus drug effects
Dengue Virus immunology
Ficusin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1556-679X
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and vaccine immunology : CVI
- Publication Type :
- Academic Journal
- Accession number :
- 20007362
- Full Text :
- https://doi.org/10.1128/CVI.00353-09