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Variable Field Proton-Electron Double-Resonance Imaging: Application to pH mapping of aqueous samples.

Authors :
Khramtsov VV
Caia GL
Shet K
Kesselring E
Petryakov S
Zweier JL
Samouilov A
Source :
Journal of magnetic resonance (San Diego, Calif. : 1997) [J Magn Reson] 2010 Feb; Vol. 202 (2), pp. 267-73. Date of Electronic Publication: 2009 Nov 26.
Publication Year :
2010

Abstract

A new concept of Variable Field Proton-Electron Double-Resonance Imaging (VF PEDRI) is proposed. This allows for functional mapping using specifically designed paramagnetic probes (e.g. oxygen or pH mapping) with MRI high quality spatial resolution and short acquisition time. Studies performed at 200 G field MRI with phantoms show that a pH map of the sample can be extracted using only two PEDRI images acquired in 140 s at pre-selected EPR excitation fields providing pH resolution of 0.1 pH units and a spatial resolution of 1.25mm. Note that while concept of functional VF PEDRI was demonstrated using the pH probe, it can be applied for studies of other biologically relevant parameters of the medium such as redox state, concentrations of oxygen or glutathione using specifically designed EPR probes.<br /> (Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1096-0856
Volume :
202
Issue :
2
Database :
MEDLINE
Journal :
Journal of magnetic resonance (San Diego, Calif. : 1997)
Publication Type :
Academic Journal
Accession number :
20007019
Full Text :
https://doi.org/10.1016/j.jmr.2009.11.017