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Poxviruses taking a ride on actin: new users of known hardware.

Authors :
Rottner K
Stradal TE
Source :
Cell host & microbe [Cell Host Microbe] 2009 Dec 17; Vol. 6 (6), pp. 497-9.
Publication Year :
2009

Abstract

Vaccinia virus uses A36 to recruit the actin polymerization effectors Nck and N-WASP to drive actin tail formation. Now, Dodding and Way identify functional orthologs of A36 in other vertebrate poxviruses that harbor varying numbers of Nck-binding sites and can substitute for A36 despite no sequence homology.

Subjects

Subjects :
Adaptor Proteins, Signal Transducing genetics
Humans
Oncogene Proteins genetics
Poxviridae genetics
Poxviridae Infections genetics
Poxviridae Infections virology
Viral Proteins genetics
Viral Proteins metabolism
Wiskott-Aldrich Syndrome Protein, Neuronal genetics
Actins metabolism
Adaptor Proteins, Signal Transducing metabolism
Oncogene Proteins metabolism
Poxviridae metabolism
Poxviridae Infections metabolism
Wiskott-Aldrich Syndrome Protein, Neuronal metabolism

Details

Language :
English
ISSN :
1934-6069
Volume :
6
Issue :
6
Database :
MEDLINE
Journal :
Cell host & microbe
Publication Type :
Academic Journal
Accession number :
20006837
Full Text :
https://doi.org/10.1016/j.chom.2009.11.010
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