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Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies.

Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies.

Authors :
Malvy D
Ezzedine K
Mamani-Matsuda M
Autran B
Tolou H
Receveur MC
Pistone T
Rambert J
Moynet D
Mossalayi D
Source :
BMC infectious diseases [BMC Infect Dis] 2009 Dec 10; Vol. 9, pp. 200. Date of Electronic Publication: 2009 Dec 10.
Publication Year :
2009

Abstract

Background: Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.<br />Case Presentation: We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.<br />Conclusions: Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.

Details

Language :
English
ISSN :
1471-2334
Volume :
9
Database :
MEDLINE
Journal :
BMC infectious diseases
Publication Type :
Academic Journal
Accession number :
20003320
Full Text :
https://doi.org/10.1186/1471-2334-9-200