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Differences between tuberculosis cases infected with Mycobacterium africanum, West African type 2, relative to Euro-American Mycobacterium tuberculosis: an update.
- Source :
-
FEMS immunology and medical microbiology [FEMS Immunol Med Microbiol] 2010 Feb; Vol. 58 (1), pp. 102-5. Date of Electronic Publication: 2009 Nov 03. - Publication Year :
- 2010
-
Abstract
- Mycobacterium africanum (MAF) is a common cause of human pulmonary tuberculosis in West Africa. We previously described phenotypic differences between MAF and Mycobacterium tuberculosis (MTB) among 290 patients. In the present analysis, we compared 692 tuberculosis patients infected with the two most common lineages within the (MTB) complex found in the Gambia, namely MAF West African type 2 (39% prevalence) and Euro-American MTB (55% prevalence). We identified additional phenotypic differences between infections with these two organisms. MAF patients were more likely to be older and HIV infected. In addition, they had worse disease on chest X-ray, despite complaining of cough for an equal duration, and were more likely severely malnourished. In this cohort, the prevalence of MAF did not change significantly over a 7-year period.
- Subjects :
- AIDS-Related Opportunistic Infections epidemiology
AIDS-Related Opportunistic Infections microbiology
AIDS-Related Opportunistic Infections physiopathology
Adult
Americas epidemiology
Europe epidemiology
Female
Gambia epidemiology
Genotype
Humans
Male
Mycobacterium classification
Mycobacterium genetics
Mycobacterium tuberculosis classification
Mycobacterium tuberculosis genetics
Phenotype
Prevalence
Young Adult
HIV Infections complications
HIV Infections epidemiology
HIV Infections virology
Malnutrition complications
Malnutrition epidemiology
Mycobacterium pathogenicity
Mycobacterium tuberculosis pathogenicity
Tuberculosis, Pulmonary epidemiology
Tuberculosis, Pulmonary microbiology
Tuberculosis, Pulmonary physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1574-695X
- Volume :
- 58
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEMS immunology and medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 20002176
- Full Text :
- https://doi.org/10.1111/j.1574-695X.2009.00628.x