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A protective effect of caffeine on drosophila larvae treated with methyl methanesulfonate.
- Source :
-
Mutation research [Mutat Res] 1977 Oct; Vol. 45 (1), pp. 41-5. - Publication Year :
- 1977
-
Abstract
- Lethality induced in larval populations of Drosophila melanogaster was recorded after treatment with (1) caffeine, (2) MMS or (3) caffeine plus MMS. The mixture of caffeine plus MMS was less toxic than expected from the effects observed after treatment with either substance individually. It is postulated that in the combined treatment the caffeine, by inhibiting semiconservative DNA replication, allows for some additional time for repair of alkylated DNA by a repair pathway which is not sensitive to caffeine, possibly excision repair.
- Subjects :
- Animals
DNA Repair drug effects
DNA Replication drug effects
Drosophila melanogaster drug effects
Larva genetics
Methyl Methanesulfonate pharmacology
Mutagens
Mutation
Caffeine pharmacology
Drosophila melanogaster genetics
Genes, Lethal
Mesylates antagonists & inhibitors
Methyl Methanesulfonate antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0027-5107
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Mutation research
- Publication Type :
- Academic Journal
- Accession number :
- 199836
- Full Text :
- https://doi.org/10.1016/0027-5107(77)90041-0