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Effect of carnosine against thioacetamide-induced liver cirrhosis in rat.
- Source :
-
Peptides [Peptides] 2010 Jan; Vol. 31 (1), pp. 67-71. Date of Electronic Publication: 2009 Dec 01. - Publication Year :
- 2010
-
Abstract
- Carnosine (beta-alanyl-L-histidine) is a dipeptide with antioxidant properties. Oxidative stress has been proposed to be involved in thioacetamide (TAA)-induced liver cirrhosis in rats, that is similar to human disease. In this study we aimed to investigate the role of carnosine on the development of TAA-induced cirrhosis. 200mg TAA/kg body weight has been given i.p. twice a week for three months to female wistar rats. Another group received same dose of TAA in the same pattern plus 2g carnosine/L of drinking water for three months. TAA administration resulted in hepatic fibrosis, significant increases in plasma transaminase activities as well as hepatic hydroxyproline and lipid peroxide levels, while liver glutathione (GSH) and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) protein expressions and activities decreased. Carnosine was found to behave as an antioxidant reducing malondialdehyde (MDA) and diene conjugate (DC) levels although it was not effective on increased transaminase activities and decreased antioxidants. It also did not affect the histopathological changes observed in TAA group. Thus our findings indicate that carnosine appears to attenuate peroxidation as an antioxidant itself but does not seem to prevent the development of TAA-induced cirrhotic process.
- Subjects :
- Alanine Transaminase metabolism
Animals
Antioxidants metabolism
Aspartate Aminotransferases metabolism
Carnosine metabolism
Female
Glutathione metabolism
Glutathione Peroxidase metabolism
Humans
Liver cytology
Liver enzymology
Liver pathology
Liver Cirrhosis metabolism
Liver Cirrhosis pathology
Malondialdehyde metabolism
Oxidative Stress drug effects
Rats
Rats, Wistar
Superoxide Dismutase metabolism
Thioacetamide administration & dosage
Thioacetamide metabolism
Antioxidants pharmacology
Carnosine pharmacology
Liver drug effects
Liver Cirrhosis chemically induced
Thioacetamide toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5169
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Peptides
- Publication Type :
- Academic Journal
- Accession number :
- 19958806
- Full Text :
- https://doi.org/10.1016/j.peptides.2009.11.028