Expression of interferon-alpha and Mx protein in the livers of pigs experimentally infected with swine hepatitis E virus.

Authors :: Lee YH
Ha Y
Chae C
Source :: Journal of comparative pathology [J Comp Pathol] 2010 Feb-Apr; Vol. 142 (2-3), pp. 187-92. Date of Electronic Publication: 2009 Dec 01.
Publication Year :: 2010
Abstract: Expression of interferon-alpha (IFN-alpha) and Mx protein in the livers of pigs experimentally infected with swine hepatitis E virus (HEV) was examined immunohistochemically. Five infected and five non-infected pigs were killed at 3, 7, 14, 21, 29 and 50 days post-inoculation (dpi). Tissues were collected from each pig at necropsy. Multifocal lymphoplasmacytic hepatitis (P=0.042) and focal hepatocellular necrosis (P=0.037) were significantly more frequent in the swine HEV-infected pigs than in the non-infected control pigs. Immunohistochemical analysis detected expression of IFN-alpha and Mx protein by macrophages/Kupffer cells, lymphocytes and hepatocytes in the livers of infected pigs.<br /> (Copyright 2009 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Hepatitis E metabolism
Hepatitis E virology
Hepatitis E virus
Hepatitis, Viral, Animal metabolism
Hepatitis, Viral, Animal virology
Immunohistochemistry
In Situ Hybridization
Interferon-alpha genetics
Liver virology
Myxovirus Resistance Proteins
RNA, Messenger metabolism
Swine
Swine Diseases virology
GTP-Binding Proteins metabolism
Hepatitis E veterinary
Interferon-alpha metabolism
Liver metabolism
Swine Diseases metabolism

Full Text Access

Tools