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Is HIV-associated tuberculosis a risk factor for the development of cryptococcal disease?
- Source :
-
AIDS (London, England) [AIDS] 2010 Feb 20; Vol. 24 (4), pp. 612-4. - Publication Year :
- 2010
-
Abstract
- Cryptococcal meningitis and tuberculosis are leading causes of mortality in patients initiating antiretroviral therapy in Africa. We hypothesized that a history of tuberculosis may predispose to the development of cryptococcal meningitis and examined the association using multivariate logistic regression in a cohort of patients initiating antiretroviral therapy. History of pulmonary tuberculosis was independently associated with the development of cryptococcal meningitis (odds ratio = 6.6; 95% confidence interval = 1.3-32.7) after adjustment for covariates, including CD4 cell counts. A number of potential mechanisms may underlie this association.
- Subjects :
- AIDS-Related Opportunistic Infections virology
Adult
Antiretroviral Therapy, Highly Active
Female
Humans
Male
Meningitis, Cryptococcal virology
Regression Analysis
Risk Factors
South Africa
Tuberculosis, Pulmonary virology
AIDS-Related Opportunistic Infections complications
Meningitis, Cryptococcal etiology
Tuberculosis, Pulmonary complications
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 19952711
- Full Text :
- https://doi.org/10.1097/QAD.0b013e32833547f7