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Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics.
- Source :
-
Viral immunology [Viral Immunol] 2009 Dec; Vol. 22 (6), pp. 457-62. - Publication Year :
- 2009
-
Abstract
- Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-kappaB (NF-kappaB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-kappaB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.
- Subjects :
- Animals
CSK Tyrosine-Protein Kinase
Defective Viruses physiology
Drug Delivery Systems
In Vitro Techniques
Mice
NF-kappa B p50 Subunit metabolism
Phosphorylation
Pichinde virus physiology
Protein Processing, Post-Translational
Protein Transport
Protein-Tyrosine Kinases metabolism
Signal Transduction
Transcription Factor RelA metabolism
Transcription, Genetic
Virulence
src-Family Kinases
Arenaviridae Infections drug therapy
Defective Viruses pathogenicity
Monocytes virology
NF-kappa B metabolism
Pichinde virus pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8976
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Viral immunology
- Publication Type :
- Academic Journal
- Accession number :
- 19951183
- Full Text :
- https://doi.org/10.1089/vim.2009.0034