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Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 01; Vol. 20 (1), pp. 60-4. Date of Electronic Publication: 2009 Nov 13. - Publication Year :
- 2010
-
Abstract
- Based on the promising drug resistance profile and potent anti-HIV activity of beta-d-3'-azido-2',3'-dideoxyguanosine, a series of purine modified nucleosides were synthesized by a chemical transglycosylation reaction and evaluated for their antiviral activity, cytotoxicity, and intracellular metabolism. Among the synthesized compounds, several show potent and selective anti-HIV activity in primary lymphocytes.<br /> (Published by Elsevier Ltd.)
- Subjects :
- Anti-HIV Agents chemistry
Anti-HIV Agents toxicity
Dideoxynucleosides chemistry
Dideoxynucleosides toxicity
Glycosylation
HIV Reverse Transcriptase metabolism
Humans
Lymphocytes drug effects
Lymphocytes immunology
Anti-HIV Agents chemical synthesis
Dideoxynucleosides chemical synthesis
HIV Reverse Transcriptase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19948402
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.11.031