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Adenovirus-derived vectors for prostate cancer gene therapy.
- Source :
-
Human gene therapy [Hum Gene Ther] 2010 Jul; Vol. 21 (7), pp. 795-805. - Publication Year :
- 2010
-
Abstract
- Prostate cancer is a leading cause of death among men in Western countries. Whereas the survival rate approaches 100% for patients with localized cancer, the results of treatment in patients with metastasized prostate cancer at diagnosis are much less successful. The patients are usually presented with a variety of treatment options, but therapeutic interventions in prostate cancer are associated with frequent adverse side effects. Gene therapy and oncolytic virus therapy may constitute new strategies. Already a wide variety of preclinical studies has demonstrated the therapeutic potential of such approaches, with oncolytic prostate-specific adenoviruses as the most prominent vector. The state of the art and future prospects of gene therapy in prostate cancer are reviewed, with a focus on adenoviral vectors. We summarize advances in adenovirus technology for prostate cancer treatment and highlight areas where further developments are necessary.
Details
- Language :
- English
- ISSN :
- 1557-7422
- Volume :
- 21
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Human gene therapy
- Publication Type :
- Academic Journal
- Accession number :
- 19947826
- Full Text :
- https://doi.org/10.1089/hum.2009.203