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Alginate-chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: preparation and characterization.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2010 Mar 01; Vol. 46 (2), pp. 199-205. Date of Electronic Publication: 2009 Nov 24. - Publication Year :
- 2010
-
Abstract
- Porous scaffolds composed of alginate (AG) and chitosan (CS) were fabricated by combining the formation of polyelectrolyte complex (PEC) with freeze-drying. The AG scaffold was used as a framework with uniformly distributed and interconnected pore structure. The chitosan or chitosan/hydroxyapatite (CS/HA) composite solution was introduced into the pores of AG scaffold to form PEC scaffolds. FT-IR, XRD and XPS analysis confirmed that CS or CS/HA was coated on the AG scaffold surface. Microstructure, porosity, mechanical strength and thermal stability of PEC scaffolds were also investigated. The AG-CS PEC scaffold and Ca2+ crosslinked AG scaffold showed smaller average pore diameter and lower porosity than those of uncrosslinked AG scaffold. Moreover, compared with Ca2+ crosslinked AG scaffold, AG-CS PEC scaffold exhibited higher mechanical strength and better thermal stability.<br /> (2009 Elsevier B.V. All rights reserved.)
- Subjects :
- Compressive Strength
Electrolytes
Glucuronic Acid chemical synthesis
Glucuronic Acid chemistry
Hexuronic Acids chemical synthesis
Hexuronic Acids chemistry
Microscopy, Electron, Scanning
Photoelectron Spectroscopy
Porosity
Spectroscopy, Fourier Transform Infrared
Thermogravimetry
X-Ray Diffraction
Alginates chemical synthesis
Alginates chemistry
Chitosan chemical synthesis
Chitosan chemistry
Durapatite chemical synthesis
Durapatite chemistry
Tissue Scaffolds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 46
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 19941890
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2009.11.004