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Nardostachys jatamansi protects against cerulein-induced acute pancreatitis.
- Source :
-
Pancreas [Pancreas] 2010 May; Vol. 39 (4), pp. 520-9. - Publication Year :
- 2010
-
Abstract
- Objectives: Nardostachys jatamansi belonging to the family Valerianaceae has been used as a remedy for stomach and skin ailments in Korea. The effect of N. jatamansi on acute pancreatitis (AP) has not been defined. Therefore, we investigated the effect of N. jatamansi on cerulein-induced AP.<br />Methods: In the pretreatment group, N. jatamansi was administered orally to mice at 10 and 20 mg/kg for 5 days, and the mice were intraperitoneally injected with the stable cholecystokinin analogue cerulein hourly for 6 hours. In the posttreatment group, cerulein was injected hourly for 6 hours, and N. jatamansi was administered at the indicated time (1, 3, and 5 hours after the first cerulein injection) and dose (10 and 20 mg/kg) during the cerulein injection. Blood samples were taken 6 hours later to determine the serum amylase, the lipase, and the cytokine levels. The pancreas and the lung were rapidly removed for morphologic examination, myeloperoxidase assay, and real-time reverse transcription polymerase chain reaction.<br />Results: Nardostachys jatamansi treatment attenuated the AP, as shown by the histological examination results of the pancreas and the lung, reductions in pancreatic edema, neutrophil infiltration, serum amylase and lipase levels, serum cytokine levels, and messenger RNA expressions of inflammatory mediators.<br />Conclusions: These results suggest that N. jatamansi attenuates the severity of AP and pancreatitis-associated lung injury.
- Subjects :
- Acute Disease
Amylases blood
Animals
Body Weight drug effects
Cell Survival drug effects
Cells, Cultured
Ceruletide
Cytokines blood
Cytokines genetics
Enzyme Activation drug effects
Enzyme-Linked Immunosorbent Assay
Female
Lipase blood
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases metabolism
Organ Size drug effects
Pancreas metabolism
Pancreas pathology
Pancreatitis blood
Pancreatitis chemically induced
Peroxidase metabolism
Phytotherapy
Reverse Transcriptase Polymerase Chain Reaction
Nardostachys chemistry
Pancreas drug effects
Pancreatitis prevention & control
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 39
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 19940795
- Full Text :
- https://doi.org/10.1097/MPA.0b013e3181bd93ce