Long-term observation of subunit vaccine F1-rV270 against Yersinia pestis in mice.

Authors :: Wang Z
Zhou L
Qi Z
Zhang Q
Dai R
Yang Y
Cui B
Wang H
Yang R
Wang X
Source :: Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2010 Jan; Vol. 17 (1), pp. 199-201. Date of Electronic Publication: 2009 Nov 25.
Publication Year :: 2010
Abstract: Long-term protection and antibody response for the subunit vaccine F1-rV270 were determined by using the mouse model. Antibodies to F1 and rV270 were still detectable over a period of 518 days. The complete protection against lethal challenge of Yersinia pestis could be achieved up to day 518 after primary immunization.

Subjects :: Animals
Antibodies, Bacterial blood
Antigens, Bacterial genetics
Bacterial Proteins genetics
Female
Mice
Mice, Inbred BALB C
Pore Forming Cytotoxic Proteins genetics
Survival Analysis
Vaccines, Subunit immunology
Antigens, Bacterial immunology
Bacterial Proteins immunology
Plague prevention & control
Plague Vaccine immunology
Pore Forming Cytotoxic Proteins immunology

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