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BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 2010 May; Vol. 98 (1), pp. 31-9. Date of Electronic Publication: 2009 Nov 25. - Publication Year :
- 2010
-
Abstract
- The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-beta1/beta2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular schwannomas compared to peripheral nerves. Furthermore, this upregulation may correlate with mitotic activity. Vestibular schwannoma arising from Schwann cells of the vestibular nerve are mostly benign and slow-growing. Most of the pathogenic mechanisms regulating the vestibular schwannoma growth process are unknown. An impaired growth regulation and imbalance between mitosis and apoptosis can be assumed. However, molecular mechanisms interfering with regulation of the vestibular schwannoma growth also modulated by mitogenic factors have to be identified. Neurotrophic factors are involved in regulation of developmental processes in neuronal tissues and regeneration after peripheral nerve trauma and also reveal mitogenic effects on glial cell populations. Gene expression profiles of artemin, BDNF, GDNF, TGF-beta1/beta2 and Ret were determined in the vestibular schwannoma in comparison to the peripheral nerve tissues by using semiquantitative RT-PCR. The expression data were correlated to the proliferation-associated Ki-67 labelling index. A significant higher BDNF expression was observed in the vestibular schwannoma, whereas gene expression of artemin and GDNF was upregulated in peripheral nerves. The correlation between LI and BDNF, TGF-beta1 and Ret was found to be significant in the vestibular schwannoma. Our results demonstrate a coherence between BDNF expression and proliferative activity in the vestibular schwannoma. Based on these results, we propose a pivotal role for BDNF in modulating the vestibular schwannoma growth.
- Subjects :
- Adult
Aged
Brain-Derived Neurotrophic Factor metabolism
Female
Glial Cell Line-Derived Neurotrophic Factor genetics
Glial Cell Line-Derived Neurotrophic Factor metabolism
Humans
Ki-67 Antigen metabolism
Male
Middle Aged
Nerve Tissue Proteins genetics
Nerve Tissue Proteins metabolism
Neuroma, Acoustic pathology
Peripheral Nerves metabolism
Statistics as Topic methods
Statistics, Nonparametric
Transforming Growth Factor beta1 genetics
Transforming Growth Factor beta1 metabolism
Transforming Growth Factor beta2 genetics
Transforming Growth Factor beta2 metabolism
Young Adult
Brain-Derived Neurotrophic Factor genetics
Cell Proliferation
Gene Expression Regulation, Neoplastic physiology
Neuroma, Acoustic genetics
RNA, Messenger metabolism
Up-Regulation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7373
- Volume :
- 98
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19937367
- Full Text :
- https://doi.org/10.1007/s11060-009-0063-6