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Pharmacokinetics of ertapenem following intravenous and subcutaneous infusions in patients.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2010 Feb; Vol. 54 (2), pp. 924-6. Date of Electronic Publication: 2009 Nov 23. - Publication Year :
- 2010
-
Abstract
- Steady-state pharmacokinetics of ertapenem were compared in patients after 1-g intravenous and subcutaneous (s.c.) infusions. Bioavailability was 99%+/-18% after s.c. administration, but peaks were reduced by about (43+/-29 versus 115+/-28 microg/ml) and times to peak were delayed. Simulations based on unbound concentrations show that time over the MIC should always be longer than 30% to 40% of the dosing interval, suggesting that s.c. infusion could be an alternative in patients with reduced vascular access.
- Subjects :
- Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents administration & dosage
Ertapenem
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Young Adult
beta-Lactams administration & dosage
Anti-Bacterial Agents pharmacokinetics
Infusions, Intravenous methods
Infusions, Subcutaneous methods
beta-Lactams pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 54
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 19933804
- Full Text :
- https://doi.org/10.1128/AAC.00836-09