In vivo assessment of the antimicrobial activity of a calcium-deficient apatite vancomycin drug delivery system in a methicillin-resistant Staphylococcus aureus rabbit osteomyelitis experimental model.

Authors :: Amador G
Gautier H
Le Mabecque V
Miegeville AF
Potel G
Bouler JM
Weiss P
Caillon J
Jacqueline C
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2010 Feb; Vol. 54 (2), pp. 950-2. Date of Electronic Publication: 2009 Nov 23.
Publication Year :: 2010
Abstract: The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fluid samples treated with forms of the apatite were compared to those in tissue samples receiving a constant intravenous vancomycin infusion after 4 days. This study demonstrates that using a calcium-deficient apatite loaded with vancomycin dramatically decreases the bacterial counts in bone and marrow.

Subjects :: Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Bone Marrow microbiology
Bone and Bones microbiology
Drug Delivery Systems
Female
Osteomyelitis microbiology
Rabbits
Staphylococcal Infections microbiology
Vancomycin administration & dosage
Apatites chemistry
Calcium chemistry
Methicillin-Resistant Staphylococcus aureus drug effects
Osteomyelitis drug therapy
Staphylococcal Infections drug therapy
Vancomycin pharmacology
Vancomycin therapeutic use

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