Back to Search
Start Over
Biphasic insulin aspart 30 as insulin initiation or replacement therapy: the China cohort of the IMPROVE study.
Biphasic insulin aspart 30 as insulin initiation or replacement therapy: the China cohort of the IMPROVE study.
- Source :
-
Current medical research and opinion [Curr Med Res Opin] 2010 Jan; Vol. 26 (1), pp. 101-7. - Publication Year :
- 2010
-
Abstract
- Aims: To explore safety and efficacy of BIAsp 30 as initiation or replacement therapy in routine clinical practice in patients with poorly controlled diabetes in the Chinese cohort of the IMPROVE study.<br />Methods: In the 26-week, non-interventional, observational study, Chinese subjects with diabetes started BIAsp 30 treatment in routine care. Data from patients' diaries and medical records were transferred to CRFs by participating physicians.<br />Clinical Trial Registration: NCT00659282.<br />Results: Of the 21,729 subjects enrolled (mean age 54.0 years, BMI 24.6 kg/m 2 , diabetes duration 4.86 years), 32.3% were treatment-naïve, 59.3% were from oral anti-diabetic drugs (OADs) only and 8.1% were from insulin +/- OADs. Overall, mean HbA(1c) and FBG decreased by 2.82% and 5 mmol/L, respectively. In the subgroups, changes were: -3.27% and -6.06 mmol/L (treatment-naïve), -2.57% and -4.54 mmol/L (OADs only), -2.96% and 3.51 mmol/L (insulin +/- OADs) all p < 0.05. HbA(1c) < 7% was achieved by 71.4% of patients. Only 0.1% of subjects reported major hypoglycaemia and 73 SADRs were observed without significant difference compared to those at baseline. Body weight did not change significantly.<br />Conclusions: Regardless of previous treatments, insulin initiation or replacement with BIAsp 30 improved glycaemic control without increasing major hypoglycaemia or weight gain in Chinese patients with diabetes.
- Subjects :
- Biphasic Insulins
Cohort Studies
Diabetes Mellitus, Type 2 physiopathology
Humans
Hypoglycemic Agents administration & dosage
Hypoglycemic Agents adverse effects
Insulin administration & dosage
Insulin adverse effects
Insulin therapeutic use
Insulin Aspart
Insulin, Isophane
Patient Satisfaction
Quality of Life
Treatment Outcome
Weight Gain drug effects
Diabetes Mellitus, Type 2 drug therapy
Hypoglycemic Agents therapeutic use
Insulin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1473-4877
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current medical research and opinion
- Publication Type :
- Academic Journal
- Accession number :
- 19916705
- Full Text :
- https://doi.org/10.1185/03007990903364640