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Biphasic insulin aspart 30 as insulin initiation or replacement therapy: the China cohort of the IMPROVE study.

Biphasic insulin aspart 30 as insulin initiation or replacement therapy: the China cohort of the IMPROVE study.

Authors :
Yang W
Gao Y
Liu G
Chen L
Fu Z
Zou D
Feng P
Zhao Z
Source :
Current medical research and opinion [Curr Med Res Opin] 2010 Jan; Vol. 26 (1), pp. 101-7.
Publication Year :
2010

Abstract

Aims: To explore safety and efficacy of BIAsp 30 as initiation or replacement therapy in routine clinical practice in patients with poorly controlled diabetes in the Chinese cohort of the IMPROVE study.<br />Methods: In the 26-week, non-interventional, observational study, Chinese subjects with diabetes started BIAsp 30 treatment in routine care. Data from patients' diaries and medical records were transferred to CRFs by participating physicians.<br />Clinical Trial Registration: NCT00659282.<br />Results: Of the 21,729 subjects enrolled (mean age 54.0 years, BMI 24.6 kg/m 2 , diabetes duration 4.86 years), 32.3% were treatment-naïve, 59.3% were from oral anti-diabetic drugs (OADs) only and 8.1% were from insulin +/- OADs. Overall, mean HbA(1c) and FBG decreased by 2.82% and 5 mmol/L, respectively. In the subgroups, changes were: -3.27% and -6.06 mmol/L (treatment-naïve), -2.57% and -4.54 mmol/L (OADs only), -2.96% and 3.51 mmol/L (insulin +/- OADs) all p < 0.05. HbA(1c) < 7% was achieved by 71.4% of patients. Only 0.1% of subjects reported major hypoglycaemia and 73 SADRs were observed without significant difference compared to those at baseline. Body weight did not change significantly.<br />Conclusions: Regardless of previous treatments, insulin initiation or replacement with BIAsp 30 improved glycaemic control without increasing major hypoglycaemia or weight gain in Chinese patients with diabetes.

Details

Language :
English
ISSN :
1473-4877
Volume :
26
Issue :
1
Database :
MEDLINE
Journal :
Current medical research and opinion
Publication Type :
Academic Journal
Accession number :
19916705
Full Text :
https://doi.org/10.1185/03007990903364640