Back to Search
Start Over
Organophosphorus-induced delayed neuropathy: a simple and efficient therapeutic strategy.
- Source :
-
Toxicology letters [Toxicol Lett] 2010 Feb 01; Vol. 192 (2), pp. 238-44. Date of Electronic Publication: 2009 Nov 13. - Publication Year :
- 2010
-
Abstract
- Organophosphorus (OP) used as pesticides and hydraulic fluids can produce acute poisoning known as OP-induced delayed neuropathy (OPIDN), whose effects take long time to recover. Thus a secure therapeutic strategy to prevent the most serious effects of this poisoning would be welcome. In this study, tri-o-cresyl phosphate (TOCP, 500 mg/kg p.o.) was given to hens, followed or not by nimodipine (1mg/kg i.m.) and calcium gluconate (Ca-glu 5mg/kg i.v.). Six hours after TOCP intoxication, neuropathy target esterase (NTE) activity inhibition was observed, peaking after 24h exceeding 80% inhibition. A fall in the plasmatic calcium levels was noted 12h after TOCP was given and, in the sciatic nerve, Ca(2+) fell 56.4% 24h later; at the same time calcium activated neutral protease (CANP) activity increased 308.7%, an effect that lasted 14 days. Any bird that received therapeutic treatment after TOCP intoxication presented significant signs of OPIDN. These results suggest that NTE may be implicated in the regulation of calcium entrance into cells being responsible for the maintenance of normal function of calcium channels, and that increasing CANP activity is responsible to triggering OPIDN. Thus, with one suitably adjusted dose of nimodipine as well as Ca-glu, we believe that this treatment strategy may be used in humans with acute poisoning by neuropathic OP.<br /> (2009 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Calcium blood
Calcium metabolism
Calcium Channels drug effects
Calcium Channels metabolism
Calcium Gluconate therapeutic use
Carboxylic Ester Hydrolases antagonists & inhibitors
Carboxylic Ester Hydrolases metabolism
Chickens metabolism
Disease Models, Animal
Homeostasis drug effects
Muscles metabolism
Nervous System Diseases drug therapy
Nervous System Diseases metabolism
Nimodipine therapeutic use
Nervous System Diseases chemically induced
Pesticides poisoning
Tritolyl Phosphates poisoning
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3169
- Volume :
- 192
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Toxicology letters
- Publication Type :
- Academic Journal
- Accession number :
- 19914363
- Full Text :
- https://doi.org/10.1016/j.toxlet.2009.10.032