Back to Search
Start Over
Math1 is essential for the development of hindbrain neurons critical for perinatal breathing.
- Source :
-
Neuron [Neuron] 2009 Nov 12; Vol. 64 (3), pp. 341-54. - Publication Year :
- 2009
-
Abstract
- Mice lacking the proneural transcription factor Math1 (Atoh1) lack multiple neurons of the proprioceptive and arousal systems and die shortly after birth from an apparent inability to initiate respiration. We sought to determine whether Math1 was necessary for the development of hindbrain nuclei involved in respiratory rhythm generation, such as the parafacial respiratory group/retrotrapezoid nucleus (pFRG/RTN), defects in which are associated with congenital central hypoventilation syndrome (CCHS). We generated a Math1-GFP fusion allele to trace the development of Math1-expressing pFRG/RTN and paratrigeminal neurons and found that loss of Math1 did indeed disrupt their migration and differentiation. We also identified Math1-dependent neurons and their projections near the pre-Bötzinger complex, a structure critical for respiratory rhythmogenesis, and found that glutamatergic modulation reestablished a rhythm in the absence of Math1. This study identifies Math1-dependent neurons that are critical for perinatal breathing that may link proprioception and arousal with respiration.
- Subjects :
- Animals
Basic Helix-Loop-Helix Transcription Factors genetics
Cell Movement physiology
Glutamic Acid metabolism
Green Fluorescent Proteins genetics
Hypoventilation embryology
Hypoventilation physiopathology
In Vitro Techniques
Medulla Oblongata embryology
Medulla Oblongata physiology
Mice
Mice, Knockout
Mice, Transgenic
Neurogenesis physiology
Rhombencephalon cytology
Basic Helix-Loop-Helix Transcription Factors metabolism
Neurons physiology
Periodicity
Respiratory Mechanics physiology
Rhombencephalon embryology
Rhombencephalon physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 64
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 19914183
- Full Text :
- https://doi.org/10.1016/j.neuron.2009.10.023