Back to Search
Start Over
Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.
- Source :
-
Journal of natural products [J Nat Prod] 2009 Dec; Vol. 72 (12), pp. 2158-62. - Publication Year :
- 2009
-
Abstract
- Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC(50) 2.31 muM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 72
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 19904996
- Full Text :
- https://doi.org/10.1021/np900549e