Thyroid receptor agonists for the treatment of androgenetic alopecia.

Authors :: Li JJ
Mitchell LH
Dow RL
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 01; Vol. 20 (1), pp. 306-8. Date of Electronic Publication: 2009 Oct 29.
Publication Year :: 2010
Abstract: A thyroid hormone receptor beta subtype-selective thyromimetic 5 was found to be efficacious in both mouse and monkey hair growth models after topical applications. It penetrates the skin according to the test in human cadaver skin mounted onto Franz diffusion chambers. The serum drug level of 5 is below the limit of quantification during tests in the bald stump-tailed macaques (Macaca arctoides). It is tested negative in the 3T3 neutral red uptake (NRU) phototoxicity test, indicating a low risk for causing photo-irritation. It is also rapidly metabolized according to the PK data, thus the systemic exposure is limited.<br /> (Copyright 2009 Elsevier Ltd. All rights reserved.)