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Exploring the optimal combination therapy in hypertensive patients with diabetes mellitus.
- Source :
-
Expert review of cardiovascular therapy [Expert Rev Cardiovasc Ther] 2009 Nov; Vol. 7 (11), pp. 1349-61. - Publication Year :
- 2009
-
Abstract
- Diabetes causes approximately 2.9 million deaths yearly, mainly through an increased risk of cardiovascular disease. In hypertensive diabetics, blood pressure reduction determines a significantly lower rate of cardiovascular and renal events. Conversely, reaching the generally recommended target of lower than 130/80 mmHg is a difficult challenge and, in most cases, two or more antihypertensive drugs are required. Until recently, there was a general consensus that combination treatment should include a diuretic as one of the two fundamental agents. However, recently published trials using calcium channel blockers plus renin-angiotensin system-blocking agents showed that such a combination reduces the risk of major cardiovascular events, provides greater renoprotection, and improves metabolic outcomes as compared with diuretic-based combinations. The present review explores the potential for an 'optimal' combination therapy in patients with diabetes mellitus and hypertension, in view of recent experimental and clinical evidence.
- Subjects :
- Blood Pressure drug effects
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 physiopathology
Drug Combinations
Humans
Hypertension complications
Hypertension physiopathology
Renin-Angiotensin System drug effects
Angiotensin II Type 1 Receptor Blockers therapeutic use
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Calcium Channel Blockers therapeutic use
Diabetes Mellitus, Type 2 drug therapy
Diuretics therapeutic use
Hypertension drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8344
- Volume :
- 7
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Expert review of cardiovascular therapy
- Publication Type :
- Academic Journal
- Accession number :
- 19900018
- Full Text :
- https://doi.org/10.1586/erc.09.133