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Comparison of beta-catenin with TGF-beta1, HIF-1alpha and patients' disease-free survival in human colorectal cancer.
- Source :
-
Pathology oncology research : POR [Pathol Oncol Res] 2010 Sep; Vol. 16 (3), pp. 311-8. Date of Electronic Publication: 2009 Nov 08. - Publication Year :
- 2010
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Abstract
- Beta-catenin accumulation is suppressed by TGF-beta1 (transforming growth factor beta1) in intestinal epithelium suggesting negative feedback between these two factors. Besides that, beta-catenin interacts with HIF-1alpha (hypoxia-inducible factor-1alpha) at the promoter region of HIF-1 target genes. Our study was aimed at comparison of beta-catenin with HIF-1alpha, TGF-beta1, Ki67 and survival of sporadic colorectal cancer patients. Expressions of beta-catenin, TGF-beta1, HIF-1alpha, Ki67 were evaluated in triads of specimens of each primary tumor of 72 sporadic colorectal cancers with immunohistochemistry due to limited availability of tissue material. Disease-free survival was analyzed in case of all 100 beta-catenin stained tumors, in 85 cancers stained for HIF-1 and in 72 neoplasms with TGFbeta1 staining. Beta-catenin, TGF-beta1 and HIF-1alpha accumulated in 72 colorectal cancer cells. Beta-catenin correlated both with HIF-1alpha and TGF-beta1 in all colorectal cancers (p < 0.009, r = 0.307 and p = 0.003, r = 0.342, respectively) and in subgroups of different clinico-pathological profile. Beta-catenin failed to correlate with Ki67. In case of beta-catenin, TGF-beta1 and HIF-1alpha, disease-free survival curves failed to show any statistically significant differences between groups of marker negative tumors, cancers with low expression and neoplasms with higher protein expression. Positive correlations between beta-catenin and TGF-beta1 may indicate ineffective attempts of TGF-beta1 to reduce intracellular level of beta-catenin in colorectal cancer. Associations between beta-catenin and HIF-1alpha reflect previously detected interactions between HIF-1alpha with beta-catenin and are confirmative for presence of such reactions in human colorectal cancer.
- Subjects :
- Colorectal Neoplasms mortality
Colorectal Neoplasms pathology
Disease-Free Survival
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Neoplasm Staging
Biomarkers, Tumor analysis
Colorectal Neoplasms metabolism
Hypoxia-Inducible Factor 1, alpha Subunit biosynthesis
Transforming Growth Factor beta1 biosynthesis
beta Catenin biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2807
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pathology oncology research : POR
- Publication Type :
- Academic Journal
- Accession number :
- 19898961
- Full Text :
- https://doi.org/10.1007/s12253-009-9217-2