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Variability of response time as a predictor of methylphenidate treatment response in korean children with attention deficit hyperactivity disorder.

Authors :
Lee SH
Song DH
Kim BN
Joung YS
Ha EH
Cheon KA
Shin YJ
Yoo HJ
Shin DW
Source :
Yonsei medical journal [Yonsei Med J] 2009 Oct 31; Vol. 50 (5), pp. 650-5. Date of Electronic Publication: 2009 Oct 21.
Publication Year :
2009

Abstract

Purpose: Methylphenidate (MPH) is an effective medication for the treatment of attention deficit hyperactivity disorder (ADHD). However, about 30% of patients do not respond to or are unable to tolerate MPH. Based on previous findings, we hypothesized that great variability in response time (RT) among Korean children with ADHD on a computerized continuous performance attention test would be related to poor MPH treatment response.<br />Materials and Methods: Children (ages 6-18 years) with ADHD were recruited for a prospective 12-week, open-labeled, multicenter study to examine optimal dosage of OROS methylphenidate. Of the 144 subjects selected, 28 dropped out due to adverse events, medication noncompliance, or follow-up loss, and an additional 26 subjects with comorbid disorders were excluded from statistical analyses. We defined 'responders' as subjects who received a score of less than 18 on the attention deficit hyperactivity disorder rating scale (ARS; Korean version, K-ARS) and a score of 1 or 2 on the Clinical Global Impression-Improvement scale (CGI-I). RT variability was assessed with the ADHD diagnostic system (ADS).<br />Results: Fifty-nine (67%) subjects responded to MPH treatment. The non-responders showed greater RT variability at baseline (Mann Whitney U = 577.0, p < 0.01). Baseline RT variability was a significant predictor of MPH response (Nagelkerke R(2) = 0.136, p < 0.01). It predicted 94.9% of responder, 17.2% of non-responder and 69.3% of overall group.<br />Conclusion: High RT variability may predict poor response to MPH treatment in children with ADHD.

Details

Language :
English
ISSN :
1976-2437
Volume :
50
Issue :
5
Database :
MEDLINE
Journal :
Yonsei medical journal
Publication Type :
Academic Journal
Accession number :
19881968
Full Text :
https://doi.org/10.3349/ymj.2009.50.5.650