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Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C.
Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2009 Dec 25; Vol. 390 (4), pp. 1255-9. Date of Electronic Publication: 2009 Oct 28. - Publication Year :
- 2009
-
Abstract
- The antifungal effects and mechanisms of Styraxjaponoside C were investigated. Styraxjaponoside C was active against several human pathogens, including Candida albicans. Styraxjaponoside C induced a series of cellular changes characteristic of apoptosis in C. albicans, including increased reactive oxygen species (ROS) production, measured by DHR-123 staining; phosphatidylserine externalization, visualized by Annexin V staining; DNA fragmentation, as seen by TUNEL; and plasma membrane depolarization, observed by DiBAC(4)(3) staining. The plasma membrane depolarization is likely to be associated with production of ROS. The current study suggests that Styraxjaponoside C exerts an antifungal effect by promoting apoptosis.
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 390
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 19878645
- Full Text :
- https://doi.org/10.1016/j.bbrc.2009.10.131