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Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C.

Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C.

Authors :
Park C
Woo ER
Lee DG
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2009 Dec 25; Vol. 390 (4), pp. 1255-9. Date of Electronic Publication: 2009 Oct 28.
Publication Year :
2009

Abstract

The antifungal effects and mechanisms of Styraxjaponoside C were investigated. Styraxjaponoside C was active against several human pathogens, including Candida albicans. Styraxjaponoside C induced a series of cellular changes characteristic of apoptosis in C. albicans, including increased reactive oxygen species (ROS) production, measured by DHR-123 staining; phosphatidylserine externalization, visualized by Annexin V staining; DNA fragmentation, as seen by TUNEL; and plasma membrane depolarization, observed by DiBAC(4)(3) staining. The plasma membrane depolarization is likely to be associated with production of ROS. The current study suggests that Styraxjaponoside C exerts an antifungal effect by promoting apoptosis.

Details

Language :
English
ISSN :
1090-2104
Volume :
390
Issue :
4
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
19878645
Full Text :
https://doi.org/10.1016/j.bbrc.2009.10.131