Back to Search
Start Over
Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Dec 01; Vol. 19 (23), pp. 6806-9. Date of Electronic Publication: 2009 Oct 20. - Publication Year :
- 2009
-
Abstract
- The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some 'dual-action' compounds targeting both FAAH and TRPV1 or TRPA1 receptors.
- Subjects :
- Carbamates chemistry
Dose-Response Relationship, Drug
Drug Design
Ligands
Molecular Structure
Stereoisomerism
Structure-Activity Relationship
Urea chemistry
Amidohydrolases antagonists & inhibitors
Carbamates chemical synthesis
Carbamates pharmacology
Transient Receptor Potential Channels antagonists & inhibitors
Urea chemical synthesis
Urea pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19875281
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.09.033