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Characterization of T(2)* heterogeneity in human brain white matter.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 2009 Dec; Vol. 62 (6), pp. 1652-7. - Publication Year :
- 2009
-
Abstract
- Recent in vivo MRI studies at 7.0 T have demonstrated extensive heterogeneity of T(2)* relaxation in white matter of the human brain. In order to study the origin of this heterogeneity, we performed T(2)* measurements at 1.5, 3.0, and 7.0 T in normal volunteers. Formalin-fixed brain tissue specimens were also studied using T(2)*-weighted MRI, histologic staining, chemical analysis, and electron microscopy. We found that T(2)* relaxation rate (R(2)* = 1/T(2)*) in white matter in living human brain is linearly dependent on the main magnetic field strength, and the T(2)* heterogeneity in white matter observed at 7.0 T can also be detected, albeit more weakly, at 1.5 and 3.0 T. The T(2)* heterogeneity exists also in white matter of the formalin-fixed brain tissue specimens, with prominent differences between the major fiber bundles such as the cingulum (CG) and the superior corona radiata. The white matter specimen with substantial difference in T(2)* has no significant difference in the total iron content, as determined by chemical analysis. On the other hand, evidence from histologic staining and electron microscopy demonstrates these tissue specimens have apparent difference in myelin content and microstructure.<br /> ((c) 2009 Wiley-Liss, Inc.)
- Subjects :
- Adult
Algorithms
Computer Simulation
Female
Humans
Image Enhancement methods
Male
Brain anatomy & histology
Brain physiology
Image Interpretation, Computer-Assisted methods
Magnetic Resonance Imaging methods
Models, Biological
Nerve Fibers, Myelinated physiology
Nerve Fibers, Myelinated ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2594
- Volume :
- 62
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19859939
- Full Text :
- https://doi.org/10.1002/mrm.22156