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The evolution of class V POU domain transcription factors in vertebrates and their characterisation in a marsupial.
- Source :
-
Developmental biology [Dev Biol] 2010 Jan 01; Vol. 337 (1), pp. 162-70. Date of Electronic Publication: 2009 Oct 19. - Publication Year :
- 2010
-
Abstract
- POU5F1 (OCT4) encodes a master regulator of pluripotency that is present in all mammals. A paralogue, POU2, is also present in the genomes of marsupials and monotremes and is an orthologue of zebrafish pou2 and chicken POUV. We explored the evolution of class V POU domain transcription factors and show that POU5F1 arose by gene duplication of pou2 early in the evolution of tetrapods and is not mammal-specific, as previously thought. Instead, either POU5F1 or POU2/POUV has become extinct independently in various lineages, although all gnathostomes appear to possess at least one or the other. In the tammar wallaby, POU5F1 expression is limited to pluripotent cell types (embryonic tissues and germ cells). POU2 is similarly expressed in pluripotent tissues but is also expressed in a broad range of adult tissues. Thus, unlike POU5F1, the role of POU2 may not be restricted to pluripotent cell types but could have a related function such as maintaining multipotency in adult stem cells.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
Embryonic Development
Evolution, Molecular
Exons
Female
Gene Expression Regulation, Developmental
Macropodidae embryology
Molecular Sequence Data
Octamer Transcription Factor-3 genetics
Opossums embryology
POU Domain Factors chemistry
POU Domain Factors physiology
Pluripotent Stem Cells metabolism
Zebrafish Proteins genetics
Marsupialia embryology
POU Domain Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1095-564X
- Volume :
- 337
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 19850032
- Full Text :
- https://doi.org/10.1016/j.ydbio.2009.10.017