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Clinical outcome of tailored adjuvant postoperative chemoradiotherapy in IB FIGO stage cervical cancer.

Authors :
Fabrini MG
Gadducci A
Perrone F
Cosio S
Laliscia C
Pasqualetti F
Grespi S
Cionini L
Source :
Anticancer research [Anticancer Res] 2009 Oct; Vol. 29 (10), pp. 4205-10.
Publication Year :
2009

Abstract

Aim: The aim of the present report is to review a mono-institutional experience of postoperative radiotherapy in selected patients with cervical cancer.<br />Patients and Methods: Between 1999 and 2008, fifty-one patients with high-risk stage IB cervical cancer underwent tailored adjuvant postoperative radiotherapy; concurrent chemoradiotherapy was administered to patients presenting a high risk of recurrence. The median follow-up was 58 months.<br />Results: All patients were in complete remission at first follow-up assessment. Ten patients were subject to recurrences between 7 and 54 months after treatment. The 2-year and 5-year disease-free survival rates were 88.1% and 74.9%, respectively; 2-year and 5-year overall survival rates of the whole group were 91.8% and 82.0%, respectively. Only one case of grade 4 and four cases of grade 3 side effects were reported.<br />Conclusion: Tailored adjuvant postoperative chemoradiotherapy is able to obtain a satisfactory clinical outcome in patients with high-risk early-stage IB cervical cancer.

Details

Language :
English
ISSN :
1791-7530
Volume :
29
Issue :
10
Database :
MEDLINE
Journal :
Anticancer research
Publication Type :
Academic Journal
Accession number :
19846974