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Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2010 Feb 01; Vol. 75 (2), pp. 543-9. Date of Electronic Publication: 2009 Sep 26. - Publication Year :
- 2010
-
Abstract
- This research is aimed to develop a nanomicelle delivery system in order to enhance the solubility and stability of camptothecin (CPT) in aqueous media. In this case, alpha,beta-poly[(N-carboxybutyl)-L-aspartamide] (PBAsp)-CPT was conjugated by the esterification between PBAsp and 20-OH of CPT, and hence used to fabricate nanomicelles with a particle size between the pore size of blood capillary in normal tissue and that in tumor tissue. It was worthy of note that the drug-loaded system of PBAsp-CPT nanomicelle improved the solubility and stability of CPT in aqueous media. However, with an increase of the CPT loading in PBAsp-CPT, the solubility sharply decreased. Meanwhile, the sizes of PBAsp-CPT nanomicelles showed a tendency of increase. Moreover, the drug release of PBAsp-CPT nanomicelles displayed a linear sustaining profile, and hence resulted in the essential decrease of cytotoxicity to L929 cell line. The assembled nanomicelles based on the PBAsp-CPT conjugates showed a great potential as polymer prodrug of tumor therapy, and the controlled nano-scale might achieve the passive tumor targeting.
- Subjects :
- Animals
Camptothecin chemical synthesis
Camptothecin pharmacology
Cell Death drug effects
Cell Line
Cell Survival drug effects
Drug Stability
Hydrogen-Ion Concentration drug effects
Magnetic Resonance Spectroscopy
Mice
Nanostructures ultrastructure
Particle Size
Solubility drug effects
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Camptothecin analogs & derivatives
Camptothecin chemistry
Micelles
Nanostructures chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 75
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 19846282
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2009.09.034