Back to Search
Start Over
[Preliminary clinical analysis of the hepatic dysfunction in patients with acquired hemophagocytic lymphohistiocytosis].
- Source :
-
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2009 Oct; Vol. 17 (5), pp. 1356-9. - Publication Year :
- 2009
-
Abstract
- The aim of this study was to investigate the clinical features of acquired hemophagocytic lymphohistiocytosis (HLH) complicated with hepatic dysfunction. 18 cases of acquired HLH were analyzed. The characteristics of hepatic dysfunction, the relationship between hepatic dysfunction and the cause, as well as prognosis of the acquired HLH were preliminarily analysed. The results indicated that characteristics of hepatic dysfunction in acquired HLH patients were hypoproteinemia, jaundice and increase of L-aspirate aminotransferase (AST) and lactate dehydrogenase (LDH) levels. The level of AST and direct bilirubin (DBil) in the non-malignancy associated hemophagocytic lymphohistiocytosis group were higher than that in malignancy-associated hemophagocytic lymphohistiocytosis group (p<0.05). And the increase of LDH and AST levels indicated poor prognosis (p<0.05). In conclusion, liver damage is a common organ functional disorder in patients with acquired HLH, which may be correlated to the cause and the prognosis of acquired HLH.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Liver Diseases complications
Lymphohistiocytosis, Hemophagocytic complications
Lymphohistiocytosis, Hemophagocytic etiology
Male
Middle Aged
Young Adult
Liver physiopathology
Liver Diseases physiopathology
Lymphohistiocytosis, Hemophagocytic physiopathology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1009-2137
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhongguo shi yan xue ye xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 19840483